Minimally Invasive Delivery of 3D Shape Recoverable Constructs with Ordered Structures for Tissue Repair

Minimally invasive procedures are becoming increasingly more common in surgery. However, the biomaterials capable of delivering biomimetic, three-dimensional (3D) functional tissues a minimally manner and exhibiting ordered structures after delivery lacking. Herein, we reported fabrication gelatin methacryloyl (GelMA)-coated, 3D expanded nanofiber scaffolds, their potential applications tissue constructs with clinically appropriate sizes (4 cm × 2 1.5 mm). GelMA-coated, scaffolds produced by combining electrospinning, gas-foaming expansion, hydrogel coating, cross-linking extremely shape recoverable release compressive strain, displaying superelastic property. Such can be seeded various types cells, including dermal fibroblasts, bone marrow-derived mesenchymal stem human neural stem/precursor cells to form complex constructs. Importantly, developed compressed loaded into 4 mm diameter glass tube for without compromising cell viability. Taken together, method this study could hold great promise transplantation well-organized repair regeneration using like laparoscopy thoracoscopy.